报告题目：炎症与疾病
时间： 2018年10月20号 上午11:00-12:00
地点： 动科楼0126报告厅
联系人： 高帅 62734627
| 占贞贞，博士，现任同济大学附属东方医院心力衰竭研究所研究员，博导，兼医院科技办副主任。从事免疫炎症和自噬在缺血性心肺疾病、肿瘤以及感染性疾病中的作用研究。入选上海市卫生系统优秀学科带头人、上海市青年科技启明星，荣获中国免疫学青年学者奖、上海市卫生系统“银蛇奖”、中国百篇最具影响国际学术论文等荣誉。作为项目负责人主持国家自然科学基金5项、省部级课题4项等。
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主要发表论文：
1.Yang L, Wang B, Zhou Q, Wang Y, Liu X, Liu Z*, Zhan Z*. MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7. Cell Death Dis. 2018;9(7):769.
2. Liu X, Cao H, Li J, Wang B, Zhang P, Dong Zhang X, Liu Z, Yuan H*, Zhan Z*. Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination. Cell Death Differ. 2017;24(4):683-693.
3. Zhan Z*, Cao H, Xie X, Yang L, Zhang P, Chen Y, Fan H, Liu Z, Liu X*. Phosphatase PP4 negatively regulates type I interferon production and antiviral innate immunity by dephosphorylating and deactivating TBK1. The Journal of Immunology. 2015 Oct 15;195(8):3849-3857.
4.Zhan Z, Xie X, Cao H, Zhou X, Zhang XD, Fan H*, Liu Z*. Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy. 2014;10(2):257-268.
5.Zhan Z, Li Q, Wu P, Ye Y, Tseng HY, Zhang L*, Zhang XD*. Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1. Autophagy. 2012;8(1):109-121.
6.Liu X, Zhan Z, Li D, Xu L, Ma F, Zhang P, Yao H, Cao X*. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nature Immunology. 2011;12(5):416-424.
7.Liu X#, Zhan Z#, Xu L, Ma F, Li D, Guo Z, Li N, Cao X*. MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα. The Journal of Immunology. 2010;185(12):7244-7251.
欢迎广大师生前来参加！
